Clinical Characteristics of Snoring Patients with PA and OSAS
Study objectives: This study aimed to identify the clinical characteristics of snoring patients with primary aldosteronism (PA) complicated by OSAS.
Study conclusions: Patients with PA and snoring had higher BMI, diastolic blood pressure, serum and urinary sodium, and renin activity, as well as lower eGFR, aldosterone levels, and ARR than patients with PA alone. The majority of patients with snoring were confirmed to have moderateto-severe OSAS. It is essential to set a reference ARR range for patients with snoring or OSAS when screening for PA. Additionally, the prognosis of patients with PA plus OSAS receiving CPAP treatment, spironolactone, or adrenalectomy requires further investigation.
Introduction: This study aimed to identify the clinical characteristics of snoring patients with primary aldosteronism (PA) complicated by OSAS. Sixty-eight self-reported or witnessed snoring patients and 609 non-snoring patients diagnosed with PA between 2010 and 2015 were recruited in this retrospective study. Compared to non-snoring patients, snoring patients had significantly (P < 0.05) higher body mass index (BMI), diastolic blood pressure (DBP), and serum and urinary sodium, as well as lower estimated glomerular filtration rate (eGFR). Moreover, snoring patients exhibited significantly (P < 0.01) higher plasma renin activity levels and lower plasma aldosterone levels and aldosterone-to-renin activity ratios (ARRs) than patients with PA alone.